# post_variation

A write tool on the OrigeneMCP MCP server.

Agent View of the PolicyLayer registry record for `post_variation`. HTML page: https://policylayer.com/tools/gentel-lab-origenemcp/post-variation

## Facts

- Tool: `post_variation`
- Server: OrigeneMCP (`gentel-lab/origenemcp`) — https://policylayer.com/tools/gentel-lab-origenemcp.md
- Homepage: https://github.com/GENTEL-lab/OrigeneMCP
- Risk category: Write (Medium risk)
- Registry record: grade C, identity unverified
- Server rate-limited: no
- Parameters: 0
- Recommended policy verdict: Rate-limited

## Example call (MCP tools/call, JSON-RPC 2.0)

```json
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "post_variation",
    "arguments": {}
  }
}
```

## Why post_variation is rated Medium

The 'post' prefix strongly suggests a Write operation (creates or modifies data). Given the biomedical context of OrigeneMCP (variation databases like ClinVar), this tool likely submits or registers variation data. Without a description, confidence is moderate. It is classified as Write rather than Execute because 'post' implies data creation, not arbitrary command execution.

From the tool's own definition: "Tool name 'post_variation' uses the 'post' verb, which conventionally indicates data creation or submission. The description is empty, preventing definitive assessment of scope and reversibility."

## Use case

AI agents use post_variation to create or update resources in OrigeneMCP, usually the action step of a workflow, after the agent has gathered context. Every call changes real data in your OrigeneMCP environment.

## Recommended policy (PolicyLayer)

Verdict: **Rate-limited**. Enforced by the PolicyLayer MCP gateway (https://policylayer.com/mcp-gateway) before a call reaches OrigeneMCP:

```json
{
  "version": "1",
  "default": "deny",
  "tools": {
    "post_variation": {
      "limits": [
        {
          "counter": "post_variation_rate",
          "window": "minute",
          "max": 30,
          "scope": "grant"
        }
      ]
    }
  }
}
```

## Other tools on OrigeneMCP (438)

- `post_vep_hgvs` — Execute — https://policylayer.com/tools/gentel-lab-origenemcp/post-vep-hgvs.md
- `post_vep_id` — Execute — https://policylayer.com/tools/gentel-lab-origenemcp/post-vep-id.md
- `post_ga4gh_features_search` — Other — https://policylayer.com/tools/gentel-lab-origenemcp/post-ga4gh-features-search.md
- `post_lookup_id` — Other — https://policylayer.com/tools/gentel-lab-origenemcp/post-lookup-id.md
- `check_genome_accessions` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/check-genome-accessions.md
- `check_virus_accessions` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/check-virus-accessions.md
- `clinvar_find_single_mutation` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/clinvar-find-single-mutation.md
- `clinvar_get_best_refseqid_by_sequence` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/clinvar-get-best-refseqid-by-sequence.md
- `clinvar_query_sequence_variants` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/clinvar-query-sequence-variants.md
- `clinvar_query_variant_significance` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/clinvar-query-variant-significance.md
- `depmap_comprehensive_analysis` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/depmap-comprehensive-analysis.md
- `depmap_get_dependency` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/depmap-get-dependency.md
- `depmap_get_expression` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/depmap-get-expression.md
- `depmap_get_mutation` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/depmap-get-mutation.md
- `ensembl_get_genes_by_band` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/ensembl-get-genes-by-band.md
- `get_activity` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-activity.md
- `get_activity_by_id` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-activity-by-id.md
- `get_activity_by_ids` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-activity-by-ids.md
- `get_activity_supplementary_data_by_activity` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-activity-supplementary-data-by-activity.md
- `get_activity_supplementary_data_by_activity_by_id` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-activity-supplementary-data-by-activity-by-id.md
- `get_activity_supplementary_data_by_activity_by_ids` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-activity-supplementary-data-by-activity-by-ids.md
- `get_alignment_region` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-alignment-region.md
- `get_all_interaction_partners_of_the_protein_set` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-all-interaction-partners-of-the-protein-set.md
- `get_archive_id` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-archive-id.md
- `get_assay` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-assay.md
- `get_assay_by_id` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-assay-by-id.md
- `get_assay_by_ids` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-assay-by-ids.md
- `get_assay_class` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-assay-class.md
- `get_assay_class_by_id` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-assay-class-by-id.md
- `get_assay_class_by_ids` — Read — https://policylayer.com/tools/gentel-lab-origenemcp/get-assay-class-by-ids.md
- …and 408 more: https://policylayer.com/tools/gentel-lab-origenemcp.md

## For agents

This record is a snapshot. Live verdicts and the full registry:

- Check every server in your MCP config at once: `npx -y policylayer stack`
- Vet a server before you add it: install the mcp-precheck skill — `npx skills add https://policylayer.com` (skill text: https://policylayer.com/skill.md)
- Query the registry over MCP: endpoint `https://api.policylayer.com/mcp` — tools `check_mcp_server`, `check_mcp_stack`, `check_tool`, `search_registry`, `get_change_events`

---

Source: the PolicyLayer MCP registry — one continuously verified record per MCP server. Full record: https://policylayer.com/registry?q=gentel-lab-origenemcp · API: https://policylayer.com/registry/api · Policy library: https://policylayer.com/policies/gentel-lab-origenemcp