# myvariant.variants.info

Retrieve comprehensive annotation for a single genetic variant by its dbSNP rsID (e.g. "rs671") or HGVS genomic notation. Returns complete annotation from 30+ integrated databases: ClinVar clinical significance and disease conditions, CADD pathogenicity scores (raw + PHRED), gnomAD exome and genome allele frequencies across ancestry groups (AFR, EUR, EAS, AMR, ASJ), SnpEff predicted functional consequences with HGVS coding and protein notations, dbSNP allele frequency data, COSMIC somatic mutation records, CIViC clinical interpretations, and genomic coordinates in both GRCh37 (hg19) and GRCh38 (hg38). Essential for variant interpretation pipelines, pharmacogenomics analysis, and clinical variant classification (ACMG guidelines).

Agent View of the PolicyLayer registry record for `myvariant.variants.info`. HTML page: https://policylayer.com/tools/io-github-whiteknightonhorse-apibase/myvariant.variants.info

## Facts

- Tool: `myvariant.variants.info`
- Server: Apibase (`apibase-mcp-client`) — https://policylayer.com/tools/io-github-whiteknightonhorse-apibase.md
- Install: `npx -y apibase-mcp-client`
- Homepage: https://github.com/whiteknightonhorse/APIbase
- Risk category: Read (Low risk)
- Registry record: grade F, identity unverified
- Server auth posture: open
- Server rate-limited: no
- Parameters: 2 (1 required)
- Recommended policy verdict: Allowed

## Parameters

| Parameter | Type | Required | Description |
| --- | --- | --- | --- |
| `fields` | string | no | Comma-separated annotation fields to retrieve. Default: dbsnp,clinvar,cadd,gnomad_exome,gnomad_genome,snpeff,vcf,chrom,hg19. Optional: dbnsfp (functional predic |
| `variant_id` | string | yes | Variant identifier — dbSNP rsID (e.g. "rs58991260"), or HGVS genomic notation (e.g. "chr7:g.140453134A>T" — use URL-encoded form when needed). rsIDs are preferr |

Parameters from the server's own tool schema.

## Example call (MCP tools/call, JSON-RPC 2.0)

```json
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "myvariant.variants.info",
    "arguments": {
      "variant_id": "<variant_id>"
    }
  }
}
```

## Why myvariant.variants.info is rated Low

Tool queries genetic variant databases and returns annotations without modifying data.

From the tool's own definition: "Retrieve comprehensive annotation for a single genetic variant"

## Use case

AI agents call myvariant.variants.info to retrieve information from Apibase without modifying anything. It is typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.

## Recommended policy (PolicyLayer)

Verdict: **Allowed**. Enforced by the PolicyLayer MCP gateway (https://policylayer.com/mcp-gateway) before a call reaches Apibase:

```json
{
  "version": "1",
  "default": "deny",
  "tools": {
    "myvariant.variants.info": {}
  }
}
```

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## For agents

This record is a snapshot. Live verdicts and the full registry:

- Check every server in your MCP config at once: `npx -y policylayer stack`
- Vet a server before you add it: install the mcp-precheck skill — `npx skills add https://policylayer.com` (skill text: https://policylayer.com/skill.md)
- Query the registry over MCP: endpoint `https://api.policylayer.com/mcp` — tools `check_mcp_server`, `check_mcp_stack`, `check_tool`, `search_registry`, `get_change_events`

---

Source: the PolicyLayer MCP registry — one continuously verified record per MCP server. Full record: https://policylayer.com/registry?q=io-github-whiteknightonhorse-apibase · API: https://policylayer.com/registry/api · Policy library: https://policylayer.com/policies/io-github-whiteknightonhorse-apibase