"Best drug targets for [disease]" / "what genes are linked to [condition]" / "druggable targets in [disease]" — top drug-target candidates for a disease (EFO ID), scored by integrated evidence. Use for target discovery in a therapeutic area.
Part of the Opentargets server.
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AI agents call disease_associations to retrieve information from Opentargets without modifying any data. This is common in research, monitoring, and reporting workflows where the agent needs context before taking action. Because read operations don't change state, they are generally safe to allow without restrictions -- but you may still want rate limits to control API costs.
Even though disease_associations only reads data, uncontrolled read access can leak sensitive information or rack up API costs. An agent caught in a retry loop could make thousands of calls per minute. A rate limit gives you a safety net without blocking legitimate use.
Read-only tools are safe to allow by default. No rate limit needed unless you want to control costs.
{
"version": "1",
"default": "deny",
"tools": {
"disease_associations": {}
}
}See the full Opentargets policy for all 27 tools.
These attack patterns abuse exactly the kind of access disease_associations gives an agent. Each links to the full case and the policy that stops it:
Other read tools across the catalogue. The same approach applies to each: allow, with a rate cap to control cost.
"Best drug targets for [disease]" / "what genes are linked to [condition]" / "druggable targets in [disease]" — top drug-target candidates for a disease (EFO ID), scored by integrated evidence. Use for target discovery in a therapeutic area.. It is categorised as a Read tool in the Opentargets MCP Server, which means it retrieves data without modifying state.
Register the Opentargets MCP server in PolicyLayer and add a rule for disease_associations: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches Opentargets. Nothing to install.
disease_associations is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the disease_associations rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for disease_associations. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
disease_associations is provided by the Opentargets MCP server (https://gateway.pipeworx.io/opentargets/mcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Deterministic rules across all 27 Opentargets tools. Per-identity grants. Full audit log. Live in minutes. Nothing to install.
Free to start. No card required.
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