clinvar_query_variant_significance
A read tool on the Origene MCP server.
This record as markdown: /tools/gentel-lab-origenemcp/clinvar-query-variant-significance.md
What clinvar_query_variant_significance does on OrigeneMCP
AI agents call clinvar_query_variant_significance to retrieve information from OrigeneMCP without modifying anything. It is typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
Why clinvar_query_variant_significance is rated Low
The tool appears to query ClinVar for variant significance information. This is a read-only operation against a public database with no modification, deletion, or execution of arbitrary code. No financial or destructive effects possible. Confidence is moderate (0.7) rather than high because the description is empty, but the naming convention and server context strongly suggest it is a data retrieval tool.
From the tool's definition Tool name includes 'query' and 'clinvar' (a public biomedical database). The sibling tools on this server (clinvar_find_single_mutation, clinvar_get_best_refseqid_by_sequence, clinvar_query_sequence_variants) are all retrieval operations.
Attacks that exploit this kind of access
The rule that runs clinvar_query_variant_significance safely
PolicyLayer is an MCP gateway: it sits between your AI agents and OrigeneMCP, and checks every tool call against a rule you set before the call runs. Nothing changes on the server itself. For clinvar_query_variant_significance, this is the rule to start with:
clinvar_query_variant_significance is read-only, so it stays allowed. Everything else on the server is denied unless you say otherwise.
The button opens the PolicyLayer dashboard: create your workspace, connect OrigeneMCP, apply this rule, and every clinvar_query_variant_significance call is checked against it from then on.
Questions about clinvar_query_variant_significance
clinvar_query_variant_significance is a read tool on the Origene MCP server. It is categorised as a Read tool in the OrigeneMCP MCP Server, which means it retrieves data without modifying state.
Register the Origene MCP server in PolicyLayer and add a rule for clinvar_query_variant_significance: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches OrigeneMCP. Nothing to install.
clinvar_query_variant_significance is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the clinvar_query_variant_significance rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for clinvar_query_variant_significance. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
clinvar_query_variant_significance is provided by the Origene MCP server (gentel-lab/origenemcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
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