AI agents call depmap_comprehensive_analysis to retrieve information from OrigeneMCP without modifying anything — typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
The tool appears to perform analysis on DepMap (cancer dependency mapping) data, which is a read-only biomedical database query operation. The 'analysis' qualifier could suggest computational processing, but given the sibling tools (depmap_get_*) are clearly read operations and the server's stated purpose of 'information retrieval across molecules, proteins, genes, and diseases,' this most likely aggregates and…
From the tool's definition Tool name 'depmap_comprehensive_analysis' and context as part of a biomedical data retrieval platform (depmap_* tools like get_dependency, get_expression, get_mutation are read operations). No description provided, limiting specificity.
Documented attack patterns abuse exactly the kind of access depmap_comprehensive_analysis gives an agent:
PolicyLayer is an MCP gateway — it sits between your AI agents and OrigeneMCP, and nothing reaches the server without passing your rules. This is the rule we recommend for depmap_comprehensive_analysis:
{
"version": "1",
"default": "deny",
"tools": {
"depmap_comprehensive_analysis": {}
}
}depmap_comprehensive_analysis is read-only, so it stays allowed — but everything else on the server is denied unless you say otherwise.
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depmap_comprehensive_analysis. It is categorised as a Read tool in the OrigeneMCP MCP Server, which means it retrieves data without modifying state.
Register the Origene MCP server in PolicyLayer and add a rule for depmap_comprehensive_analysis: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches OrigeneMCP. Nothing to install.
depmap_comprehensive_analysis is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the depmap_comprehensive_analysis rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for depmap_comprehensive_analysis. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
depmap_comprehensive_analysis is provided by the Origene MCP server (gentel-lab/origenemcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Start from OrigeneMCP, add the rest of your stack, and see everything your agents can call. Then put policy on all of it.
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