AI agents call depmap_get_expression to retrieve information from OrigeneMCP without modifying anything — typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
The tool appears to retrieve gene expression data from the DepMap database. As a 'get' operation on a biomedical database, it is a read-only retrieval with no side effects. Even if misused by an AI agent, it cannot modify, delete, or execute code—only retrieve data. Severity is low due to limited blast radius of information disclosure in a research context.
From the tool's definition Tool name 'depmap_get_expression' follows the pattern of read-only query tools on this server (e.g., depmap_get_dependency, depmap_get_mutation, ensembl_get_genes_by_band). The 'get' verb indicates retrieval rather than modification.
Documented attack patterns abuse exactly the kind of access depmap_get_expression gives an agent:
PolicyLayer is an MCP gateway — it sits between your AI agents and OrigeneMCP, and nothing reaches the server without passing your rules. This is the rule we recommend for depmap_get_expression:
{
"version": "1",
"default": "deny",
"tools": {
"depmap_get_expression": {}
}
}depmap_get_expression is read-only, so it stays allowed — but everything else on the server is denied unless you say otherwise.
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depmap_get_expression. It is categorised as a Read tool in the OrigeneMCP MCP Server, which means it retrieves data without modifying state.
Register the Origene MCP server in PolicyLayer and add a rule for depmap_get_expression: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches OrigeneMCP. Nothing to install.
depmap_get_expression is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the depmap_get_expression rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for depmap_get_expression. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
depmap_get_expression is provided by the Origene MCP server (gentel-lab/origenemcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Start from OrigeneMCP, add the rest of your stack, and see everything your agents can call. Then put policy on all of it.
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439 OrigeneMCP tools catalogued and risk-classified — across an index of 43,000+ MCP servers.