AI agents call get_ppi_enrichment to retrieve information from OrigeneMCP without modifying anything — typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
The tool appears designed to retrieve or analyze enrichment statistics related to protein-protein interactions, which is a read-only data retrieval operation typical of biomedical research platforms. No description is provided, which moderately reduces confidence, but the naming pattern and context among other query-focused tools strongly suggest read-only functionality.
From the tool's definition Tool name 'get_ppi_enrichment' indicates retrieval of protein-protein interaction (PPI) enrichment data. The 'get_' prefix and sibling tools (check_genome_accessions, clinvar_query_sequence_variants, depmap_get_dependency, depmap_get_expression) all follow…
Documented attack patterns abuse exactly the kind of access get_ppi_enrichment gives an agent:
PolicyLayer is an MCP gateway — it sits between your AI agents and OrigeneMCP, and nothing reaches the server without passing your rules. This is the rule we recommend for get_ppi_enrichment:
{
"version": "1",
"default": "deny",
"tools": {
"get_ppi_enrichment": {}
}
}get_ppi_enrichment is read-only, so it stays allowed — but everything else on the server is denied unless you say otherwise.
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get_ppi_enrichment. It is categorised as a Read tool in the OrigeneMCP MCP Server, which means it retrieves data without modifying state.
Register the Origene MCP server in PolicyLayer and add a rule for get_ppi_enrichment: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches OrigeneMCP. Nothing to install.
get_ppi_enrichment is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the get_ppi_enrichment rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for get_ppi_enrichment. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
get_ppi_enrichment is provided by the Origene MCP server (gentel-lab/origenemcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Start from OrigeneMCP, add the rest of your stack, and see everything your agents can call. Then put policy on all of it.
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439 OrigeneMCP tools catalogued and risk-classified — across an index of 43,000+ MCP servers.