Get CAS Registry Numbers for compounds containing a specified substructure.
AI agents call get_substructure_cas to retrieve information from OrigeneMCP without modifying anything — typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
This tool performs a search/query operation with no side effects—it retrieves and returns data (CAS Registry Numbers) based on a substructure search parameter. It does not create, modify, delete, execute code, or commit financial transactions. The capability is purely informational and read-only, consistent with other retrieval tools on the server like 'check_genome_accessions' and 'clinvar_find_single_mutation'.
From the tool's definition Tool name 'get_substructure_cas' and description 'Get CAS Registry Numbers for compounds containing a specified substructure' indicate a retrieval operation that queries a chemical database to return matching CAS numbers.
Documented attack patterns abuse exactly the kind of access get_substructure_cas gives an agent:
PolicyLayer is an MCP gateway — it sits between your AI agents and OrigeneMCP, and nothing reaches the server without passing your rules. This is the rule we recommend for get_substructure_cas:
{
"version": "1",
"default": "deny",
"tools": {
"get_substructure_cas": {}
}
}get_substructure_cas is read-only, so it stays allowed — but everything else on the server is denied unless you say otherwise.
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Get CAS Registry Numbers for compounds containing a specified substructure. It is categorised as a Read tool in the OrigeneMCP MCP Server, which means it retrieves data without modifying state.
Register the Origene MCP server in PolicyLayer and add a rule for get_substructure_cas: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches OrigeneMCP. Nothing to install.
get_substructure_cas is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the get_substructure_cas rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for get_substructure_cas. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
get_substructure_cas is provided by the Origene MCP server (gentel-lab/origenemcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Start from OrigeneMCP, add the rest of your stack, and see everything your agents can call. Then put policy on all of it.
Free to start. No card required.
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