AI agents call get_vep_hgvs to retrieve information from OrigeneMCP without modifying anything — typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
VEP is a standard bioinformatics annotation tool that predicts genomic variant effects. The 'get_' naming convention combined with the biomedical database context indicates this tool retrieves pre-computed or real-time variant annotations without modifying underlying data.
From the tool's definition Tool name 'get_vep_hgvs' suggests retrieval of VEP (Variant Effect Predictor) data in HGVS (Human Genome Variation Society) format. The 'get_' prefix indicates a query/retrieval operation.
Documented attack patterns abuse exactly the kind of access get_vep_hgvs gives an agent:
PolicyLayer is an MCP gateway — it sits between your AI agents and OrigeneMCP, and nothing reaches the server without passing your rules. This is the rule we recommend for get_vep_hgvs:
{
"version": "1",
"default": "deny",
"tools": {
"get_vep_hgvs": {}
}
}get_vep_hgvs is read-only, so it stays allowed — but everything else on the server is denied unless you say otherwise.
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get_vep_hgvs. It is categorised as a Read tool in the OrigeneMCP MCP Server, which means it retrieves data without modifying state.
Register the Origene MCP server in PolicyLayer and add a rule for get_vep_hgvs: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches OrigeneMCP. Nothing to install.
get_vep_hgvs is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the get_vep_hgvs rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for get_vep_hgvs. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
get_vep_hgvs is provided by the Origene MCP server (gentel-lab/origenemcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Start from OrigeneMCP, add the rest of your stack, and see everything your agents can call. Then put policy on all of it.
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439 OrigeneMCP tools catalogued and risk-classified — across an index of 43,000+ MCP servers.