pharmgkb.pharmacology.variant_lookup
Look up pharmacogenomic details for a genetic variant by dbSNP rsID (e.g. rs1799853 for CYP2C9*2, rs4244285 for CYP2C19*2, rs12248560 for CYP2C19*17). Returns variant ID, change classification (Missense/Synonymous/Intronic), clinical significance (drug-response/pathogenic), variant type (SNP/Inde...
This record as markdown: /tools/io-github-whiteknightonhorse-apibase/pharmgkb.pharmacology.variant-lookup.md
What pharmgkb.pharmacology.variant_lookup does on Apibase
AI agents call pharmgkb.pharmacology.variant_lookup to retrieve information from Apibase without modifying anything. It is typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
| Parameter | Type | Required | Description |
|---|---|---|---|
rsid | string | Yes | dbSNP reference SNP ID for the variant (e.g. rs1799853, rs4244285, rs12248560). Must be prefixed with "rs" followed by digits. PharmGKB annotates variants with |
Parameters from the server's own tool schema.
Why pharmgkb.pharmacology.variant_lookup is rated Low
Tool retrieves reference genetic variant data without modifying records or triggering external operations.
From the tool's definition Look up pharmacogenomic details for a genetic variant by dbSNP rsID. Returns variant ID, classification, significance, type, chromosomal position, associated genes, rarity flag, and ClinVar IDs.
Attacks that exploit this kind of access
The rule that runs pharmgkb.pharmacology.variant_lookup safely
PolicyLayer is an MCP gateway: it sits between your AI agents and Apibase, and checks every tool call against a rule you set before the call runs. Nothing changes on the server itself. For pharmgkb.pharmacology.variant_lookup, this is the rule to start with:
pharmgkb.pharmacology.variant_lookup is read-only, so it stays allowed. Everything else on the server is denied unless you say otherwise.
The button opens the PolicyLayer dashboard: create your workspace, connect Apibase, apply this rule, and every pharmgkb.pharmacology.variant_lookup call is checked against it from then on.
Questions about pharmgkb.pharmacology.variant_lookup
Look up pharmacogenomic details for a genetic variant by dbSNP rsID (e.g. rs1799853 for CYP2C9*2, rs4244285 for CYP2C19*2, rs12248560 for CYP2C19*17). Returns variant ID, change classification (Missense/Synonymous/Intronic), clinical significance (drug-response/pathogenic), variant type (SNP/Indel), chromosomal position (GRCh38), associated genes, rarity flag, and ClinVar IDs. Focused on variants with known drug-response relevance. Source: PharmGKB, CC BY-SA 4.0. It is categorised as a Read tool in the Apibase MCP Server, which means it retrieves data without modifying state.
pharmgkb.pharmacology.variant_lookup accepts 1 parameter: rsid. Required: rsid. The full parameter table on this page comes from the server's own tool schema.
Register the Apibase MCP server in PolicyLayer and add a rule for pharmgkb.pharmacology.variant_lookup: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches Apibase. Nothing to install.
pharmgkb.pharmacology.variant_lookup is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the pharmgkb.pharmacology.variant_lookup rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for pharmgkb.pharmacology.variant_lookup. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
pharmgkb.pharmacology.variant_lookup is provided by the Apibase MCP server (apibase-mcp-client). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
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