Get the full merged annotation for a single human genetic variant by its HGVS id (e.g. "chr7:g.140453136A>T"). Returns annotations aggregated from dbSNP, ClinVar (pathogenicity / clinical significance), CADD and dbNSFP (deleteriousness/conservation scores), and gnomAD (population allele frequenci...
AI agents call variant to retrieve information from Mcp Myvariant without modifying anything — typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
| Parameter | Type | Required | Description |
|---|---|---|---|
id | string | Yes | An HGVS variant id, e.g. "chr7:g.140453136A>T". |
fields | string | — | Comma-separated return fields (default: all). e.g. "clinvar,gnomad_genome.af,cadd.phred". |
Parameters from the server's own tool schema.
This tool queries a variant annotation database and returns existing metadata about genetic variants. It retrieves information from established public databases (dbSNP, ClinVar, CADD, dbNSFP, gnomAD) without any side effects, modifications, or destructive actions. The use case is explicitly lookups of variant pathogenicity and population frequency, which are read-only operations.
From the tool's definition Tool description states 'Get the full merged annotation for a single human genetic variant' and 'Returns annotations aggregated from' multiple databases. The verb 'Get' and 'read' indicate pure data retrieval.
Attacks that exploit this kind of access
Get the full merged annotation for a single human genetic variant by its HGVS id (e.g. "chr7:g.140453136A>T"). Returns annotations aggregated from dbSNP, ClinVar (pathogenicity / clinical significance), CADD and dbNSFP (deleteriousness/conservation scores), and gnomAD (population allele frequencies). Use to look up a known variant and read its pathogenicity and population frequency. It is categorised as a Read tool in the Mcp Myvariant MCP Server, which means it retrieves data without modifying state.
variant accepts 2 parameters: id, fields. Required: id. The full parameter table on this page comes from the server's own tool schema.
Register the Mcp Myvariant MCP server in PolicyLayer and add a rule for variant: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches Mcp Myvariant. Nothing to install.
variant is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the variant rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for variant. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
variant is provided by the Mcp Myvariant MCP server (https://gateway.pipeworx.io/myvariant/mcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Every MCP server has a record like this.
Type a name, get the same breakdown: verified identity, auth posture, risk grade, capabilities, recommended policy.
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