Comprehensive pathogenicity assessment of a genetic variant. Evaluates variant across all regulatory modalities and provides clinical classification. Returns: - Pathogenicity score (0-1 scale) - Clinical classification (pathogenic/likely_pathogenic/uncertain/likely_benign/benign) - Evidence break...
AI agents call assess_pathogenicity to retrieve information from AlphaGenome MCP Server without modifying anything — typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
The tool performs analysis and returns a read-only assessment (score, classification, evidence breakdown) of a genetic variant. It queries/predicts genomic data without any side effects, data mutation, code execution, or financial implications. Severity is low because misuse would at worst result in incorrect clinical interpretation, but the tool itself causes no system-level harm.
From the tool's definition Pathogenicity score (0-1 scale), Clinical classification, Evidence breakdown — the tool evaluates and returns predictions/assessments about a variant; no data is created, modified, or deleted.
Attacks that exploit this kind of access
Comprehensive pathogenicity assessment of a genetic variant. Evaluates variant across all regulatory modalities and provides clinical classification. Returns: - Pathogenicity score (0-1 scale) - Clinical classification (pathogenic/likely_pathogenic/uncertain/likely_benign/benign) - Evidence breakdown (expression, splicing, TF binding impacts) Perfect for: clinical variant interpretation, pathogenicity prediction, diagnostic sequencing. Example:. It is categorised as a Read tool in the AlphaGenome MCP Server MCP Server, which means it retrieves data without modifying state.
Register the AlphaGenome MCP Server MCP server in PolicyLayer and add a rule for assess_pathogenicity: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches AlphaGenome MCP Server. Nothing to install.
assess_pathogenicity is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the assess_pathogenicity rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for assess_pathogenicity. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
assess_pathogenicity is provided by the AlphaGenome MCP Server MCP server (taehojo/alphagenome-mcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Every MCP server has a record like this.
Type a name, get the same breakdown: verified identity, auth posture, risk grade, capabilities, recommended policy.
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