AI agents call get_similarity_smiles to retrieve information from OrigeneMCP without modifying anything — typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
Based on the naming convention and context of sibling tools in OrigeneMCP (which performs data retrieval across biomedical databases), this tool likely queries chemical similarity metrics using SMILES strings without modifying data. The lack of destructive, financial, or execute semantics in the name, combined with the 'get_' accessor pattern, strongly suggests a read-only information retrieval function.
From the tool's definition Tool name 'get_similarity_smiles' indicates retrieval of similarity data for SMILES (chemical notation); the 'get_' prefix and absence of mutation/write operations in name suggest query-only behavior. Description is empty, limiting evidence precision.
Documented attack patterns abuse exactly the kind of access get_similarity_smiles gives an agent:
PolicyLayer is an MCP gateway — it sits between your AI agents and OrigeneMCP, and nothing reaches the server without passing your rules. This is the rule we recommend for get_similarity_smiles:
{
"version": "1",
"default": "deny",
"tools": {
"get_similarity_smiles": {}
}
}get_similarity_smiles is read-only, so it stays allowed — but everything else on the server is denied unless you say otherwise.
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get_similarity_smiles. It is categorised as a Read tool in the OrigeneMCP MCP Server, which means it retrieves data without modifying state.
Register the Origene MCP server in PolicyLayer and add a rule for get_similarity_smiles: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches OrigeneMCP. Nothing to install.
get_similarity_smiles is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the get_similarity_smiles rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for get_similarity_smiles. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
get_similarity_smiles is provided by the Origene MCP server (gentel-lab/origenemcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Start from OrigeneMCP, add the rest of your stack, and see everything your agents can call. Then put policy on all of it.
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439 OrigeneMCP tools catalogued and risk-classified — across an index of 43,000+ MCP servers.