Provide a protein-level missense notation variant (eg BRAF V600E) and get genomic HGVS changes that could cause it. Uses Ensembl VEP Variant Recoder.
AI agents call protein_variant_to_genomic_hgvs to retrieve information from OpenCRAVAT without modifying anything — typically the context-gathering step in research, monitoring, and reporting workflows, before the agent takes action elsewhere.
This tool retrieves or queries genetic annotation data without side effects. It takes a protein variant notation as input and returns corresponding genomic HGVS information. This is a read-only data lookup operation consistent with the annotate_* sibling tools on the OpenCRAVAT server, which are designed for data enrichment and retrieval.
From the tool's definition Tool description states it 'gets genomic HGVS changes' in response to a protein variant input. It performs a lookup/query operation using Ensembl VEP Variant Recoder to retrieve variant information.
Documented attack patterns abuse exactly the kind of access protein_variant_to_genomic_hgvs gives an agent:
PolicyLayer is an MCP gateway — it sits between your AI agents and OpenCRAVAT, and nothing reaches the server without passing your rules. This is the rule we recommend for protein_variant_to_genomic_hgvs:
{
"version": "1",
"default": "deny",
"tools": {
"protein_variant_to_genomic_hgvs": {}
}
}protein_variant_to_genomic_hgvs is read-only, so it stays allowed — but everything else on the server is denied unless you say otherwise.
Free to start. No card required.
Provide a protein-level missense notation variant (eg BRAF V600E) and get genomic HGVS changes that could cause it. Uses Ensembl VEP Variant Recoder. It is categorised as a Read tool in the OpenCRAVAT MCP Server, which means it retrieves data without modifying state.
Register the OpenCRAVAT MCP server in PolicyLayer and add a rule for protein_variant_to_genomic_hgvs: allow, deny, rate-limit, or require approval. Point your MCP client at the PolicyLayer proxy URL and the rule is enforced on every call, before it reaches OpenCRAVAT. Nothing to install.
protein_variant_to_genomic_hgvs is a Read tool with low risk. Read-only tools are generally safe to allow by default.
Yes. Add a rate_limit block to the protein_variant_to_genomic_hgvs rule in your PolicyLayer policy. For example, setting max: 10 and window: 60 limits the tool to 10 calls per minute. Rate limits are tracked per agent session and reset automatically.
Set action: deny in the PolicyLayer policy for protein_variant_to_genomic_hgvs. The AI agent will receive a policy violation error and cannot call the tool. You can also include a reason field to explain why the tool is blocked.
protein_variant_to_genomic_hgvs is provided by the OpenCRAVAT MCP server (karchinlab/oc-mcp). PolicyLayer sits as a proxy in front of this server to enforce policies before tool calls reach the server.
Start from OpenCRAVAT, add the rest of your stack, and see everything your agents can call. Then put policy on all of it.
Free to start. No card required.
7 OpenCRAVAT tools catalogued and risk-classified — across an index of 43,000+ MCP servers.